姓名：李奇璋

单位：淮北师范大学 生命科学学院

职称：讲师

学历：博士

E-mail：qizhang-li@hotmail.com；liqzh@chnu.edu.cn

研究方向：基于生物大分子的靶点发现和药理学研究及药效物质生物合成

学习、工作经历：

2022.12—今              淮北师范大学    讲师

2019.11—2022.12     湖北工业大学  讲师

2016.08—2019.06     中山大学 生命科学学院  博士

2012.02—2014.04     北京集佳知识产权代理有限公司 西安分公司

2010.03—2011.10     上海市粮食科学研究所

2007.09—2010.03     上海交通大学  农业与生物学院  硕士

2002.09—2006.06     西北农林科技大学  生命科学学院  学士

淮北师范大学创新药物研发中心执行主任；中华中医药学会会员，中国微生物学会会员，湖北省生化学会理事，西安营养学会理事；公共营养师（一级）；基因健康管理师（中级）。 《中草药》 青年编委；Appl Microbiol Biot、Front Plant Sci、Front Immunol、Front Nutr等杂志审稿人。主要从事“基于生物大分子的靶点发现和药理学研究及药效物质生物合成”。基于“物质-功效-结构-合成”的研发思路，从天然活性物质出发，挖掘新的药效物质，评价生物功能，揭示作用机制，并以结构创新为手段，以生物合成为途径，提升应用价值。在学术期刊发表论文40余篇；以第一/通讯作者在Crit Rev Food Sci、Food Funct、Phytomedicine等TOP期刊发表SCI论文20篇；总引用650余次；授权申请4项。CNKI中国优秀硕士学位论文全文数据库收录。主持湖北省教育厅科研计划项目等多个项目，作为科研骨干参与国家自然科学基金面上项目、上海市科委应用技术开发专项基金、上海市科委支撑项目、上海良友基团等多个项目。

近五年论文：

(1)    Qi-Zhang Li^#, Yu-Ying Chen^#, Qiu-Ping Liu, Zhi-Hui Feng, Lei Zhang*, Hong Zhang*. Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest. Phytomedicine. 2024. 126: 155177.

(2)    Yi-Qing Deng^#, Min Gao^#, Dong Lu^#, Qiu-Ping Liu, Run-Jing Zhang, Ji Ye, Jing Zhao, Zhi-Hui Feng, Qi-Zhang Li*, Hong Zhang*. Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities. Phytomedicine. 2024, 123: 155169. https://doi.org/10.1016/j.phymed.2023.155169.

(3)    Shang Guo, Nannan Qin, Xiuying Wang, Zanwen Zuo, Qizhang Li**, Yuliang Wang*. Freeze-dried powder of daylily bud improves bromocriptine-induced lactation disorder in rats via JAK2/STAT5 pathway. Journal of Ethnopharmacology. 2023, 313: 116536. https://doi.org/10.1016/j.jep.2023.116536.

(4)    Zanwen Zuo, Zerong Zhou, Yuzhou Chang, Yan Liu****, Yuping Shen***, Qizhang Li*, Lei Zhang**. Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer. Genes & Diseases. 2023. https://doi.org/10.1016/j.gendis.2022.11.022.

(5)    Qizhang Li*, Zerong Zhou, Cuiyu Hu, Xianbin Li, Yuzhou Chang, Yan Liu, Yuliang Wang**, Xuanwei Zhou***. Recent advances of bioactive proteins/polypeptides in the treatment of breast cancer. Food Science and Biotechnology. 2023, 32(3):265-282. https://doi.org/10.1007/s10068-022-01233-6.

(6)    Qin Wu, Zhijian Guo, Zerong Zhou, Mengyuan Jin, Qizhang Li**, Xuanwei Zhou*. Recent advances in bioactive peptides from cereal-derived Foodstuffs. International Journal of Food Sciences and Nutrition. 2022, 73(7): 875-888. https://doi.org/10.1080/09637486.2022.2104226.

(7)    Qizhang Li*, Zanwen Zuo, Yan Liu. Recent status of sesaminol and its glucosides: Synthesis, metabolism, and biological activities. Critical Reviews in Food Science and Nutrition. 2023, 63(33): 12043-12056. https://doi.org/10.1080/10408398.2022.2098248.

(8)    Qizhang Li*, Zanwen Zuo, Zerong Zhou, Yan Ji. Polyamine homeostasis-based strategies for cancer: The role of combination regimens. European Journal of Pharmacology. 2021, 910: 174456. https://doi.org/10.1016/j.ejphar.2021.174456.

(9)    Yan Liu, Qizhang Li, Liudingji Li, Xuanwei Zhou*. Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and PI3K/Akt signaling pathways. Journal of Ethnopharmacology. 2021, 275: 114130. https://doi.org/10.1016/j.jep.2021.114130.

(10) Qizhang Li^#, Xin Chen^#, Peiwen Mao, Mengyuan Jin, Qin Wu, Xuanwei Zhou*. N-Glycosylated Ganoderma lucidum immunomodulatory protein improved anti-inflammatory activity via inhibition of p38 MAPK pathway. Food & Function. 2021, 12(8): 3393-3404. https://doi.org/10.1039/d1fo00178g.

(11) Qizhang Li^#, Zhiying Wang^#, Qiang Zheng, Sen Liu*. Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2. Computational and Structural Biotechnology Journal. 2020, 18: 2200-2208. https://doi.org/10.1016/j.csbj.2020.08.016.

(12) Kedi Shao, Peiwen Mao, Qizhang Li, Liudingji Li, Yuliang Wang, Xuanwei Zhou*. Characterization of a novel fungal immunomodulatory protein, FIP-SJ75 shuffled from Ganoderma lucidum, Flammulina velutipes and Volvariella volvacea. Food and Agricultural Immunology. 2019, 30(1): 1253-1270. https://doi.org/10.1080/09540105.2019.1686467.

(13) Yuzhang Zheng, Qizhang Li, Kedi Shao, Peiwen Mao, Yan Liu, Xuanwei Zhou*. Expression of Ganoderma lucidum fungal immunomodulatory protein (FIP-glu) in Saccharomyces cerevisiae and its immunoreactivity. International Journal of Agriculture and Biology. 2019, 22(2):369-374. https://doi.org/10.17957/IJAB/15.1073.

(14) Qizhang Li, Yuzhou Chang, Zhumei He*, Lei Chen**, Xuanwei Zhou***. Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells. Journal of Cellular Physiology. 2019, 234(12): 23337-23348. https://doi.org/10.1002/jcp.28901.

(15) 刘玲, 李奇璋, 周选围**, 王玉亮*. 重组黑芝免疫调节蛋白对小鼠巨噬细胞RAW264.7向M1型分化的影响. 食品科学. 2019, 40(23): 170-175.

(16) Qizhang Li, Yuzhang Zheng, Xuanwei Zhou*. Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms. Drug Discovery Today. 2019, 24(1): 307-314. https://doi.org/10.1016/j.drudis.2018.09.014.

专利：

(1)    周选围, 胡大卫, 徐伟民, 李奇璋. N-糖基化修饰之灵芝免疫调节蛋白的应用. CN112516288A.

(2)    李奇璋, 周选围. 真菌免疫调节蛋白基因启动子、重组载体及宿主细胞. CN101705230B.

(3)    周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属间的重组真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. ZL201110068813.0.

(4)    周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属内重组的真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. ZL201110068761.7.

(5)    周选围, 李奇璋, 林娟. 编码草菇真菌免疫调节蛋白的基因序列. CN101509001A.

(6)    周选围, 林娟, 李奇璋, 尹燡周, 唐克轩. 利用特异基因序列鉴别药用灵芝的检测方法. CN 101200769.